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eu.36kr.com2026-05-29

Biology's Major Change: Zuckerberg's New Open-Source Model Dethrones Google's AlphaFold - eu.36kr.com

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Mark Zuckerberg's Biohub research institute has released a new protein structure prediction model called ESMFold2. According to the article, the model predicted 1.1 billion protein structures at once, which is 800 million more than the AlphaFold database. The model is described as completely open-source with no restrictions on commercial use.

The release positions ESMFold2 as a direct competitor to Google's AlphaFold, which has been a leading tool in computational biology. The article states that ESMFold2 has 'dethroned' AlphaFold in terms of the sheer number of structures predicted. The model's open-source nature allows anyone to access and use it without licensing fees or usage restrictions.

The implications of the release are noted in the context of accelerating biological research and potential commercial applications. The article does not discuss specific safety measures or restrictions on the model's use. The open-source availability could enable a wide range of entities, from academic labs to private companies, to leverage the model for protein structure prediction and design.

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